Accelerated reduction of organic substances with boranes

C - Chemistry – Metallurgy – 07 – B

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C07B 31/00 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2700067

In a process for the accelerated reduction of organic substrates, selected from the group consisting of ester, amides, nitriles, acids, ketones, imines or mixtures thereof, the substrates are reacted with an amine borane, sulfide borane or ether borane complex as a borane source in the presence of organic accelerator compounds containing both Lewis acidic and Lewis basic sites in their structure, of which the Lewis acidic site can coordinate with the carbonyl or nitrile or imine group of the substrate and the Lewis basic site can coordinate with the borane.

La présente invention a trait à un procédé de réduction accélérée de substrats organiques choisis dans le groupe constitué des esters, amides, nitriles, acides, cétones, imines ou mélanges de ceux-ci, dans lequel on fait réagir les substrats avec un complexe de borane et d'amine, de borane et de sulfure ou de borane et d'éther, qui sert de source de borane, en présence de composés organiques accélérateurs contenant des sites à la fois de type acide de Lewis et de type base de Lewis dans leur structure, le site de type acide de Lewis pouvant se lier avec le groupe carbonyle, nitrile ou imine du substrat et le site de type base de Lewis pouvant se lier avec le borane.

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