Accumulation of amino acids and peptides into liposomes

Details Accumulation of amino acids and peptides into liposomes Accumulation of amino acids and peptides into liposomes

A - Human Necessities

61

K

A61K 38/25 (2006.01) A61K 9/127 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/22 (2006.01) A61K 38/10 (2006.01) A61K 38/22 (2006.01)

Patent

CA 2087965

2087965 9202244 PCTABS00010 The present invention relates to liposomal compositions having a concentration gradient which load amino acids and peptides exhibiting weak acid or base characteristics into liposomes. Specifically loaded into liposomes by the methods of the present invention are C-terminal substituted amino acids or peptides. The liposomes are preferably large unilamellar vesicles. The concentration gradient is formed by encapsulating a first medium in the liposomes, said medium having a first concentration of the one or more charged species, and suspending the liposomes in a second medium having a second concentration of the one or more charged species, such as for example a pH gradient. Also disclosed are pharmaceutical preparations comprising such C-terminal substituted amino acids or peptides which have been loaded into the liposomes by the method of the invention.

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