Acellular pertussis vaccines and methods of preparation thereof

C - Chemistry – Metallurgy – 07 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07K 14/235 (2006.01) A61K 39/10 (2006.01) A61K 39/116 (2006.01) A61K 39/295 (2006.01) C07K 1/14 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2220063

A fimbrial agglutinogen preparation is prepared from a <u>Bordetella</u> strain, particularly a <u>B. pertussis</u> strain, by a multiple step procedure involving extraction of the fimbrial agglutinogens from cell paste and concentrating and purifying the extracted material. The fimbrial agglutinogen preparation may be used to prepare acellular pertussis vaccines with other pertussis antigens, including pertussis toxin or toxoid thereof, the 69 kDa protein and filamentous haemagglutonin and other <u>Bordetella</u> antigens. Such vaccines confer protection to at least 70 % of an at-risk human population.

La présente invention concerne la préparation d'un agglutinogène fimbrial à partir d'une souche <u>Bordetella</u>, et plus particulièrement d'une souche <u>Bordetella pertussis</u>, selon une procédure comportant plusieurs étapes et notamment l'extraction des agglutinogènes fimbriaux à partir d'une pâte cellulaire, puis la concentration et la purification du matériau extrait. Cette préparation d'agglutinogène fimbrial peut s'utiliser pour préparer des vaccins anticoquelucheux acellulaires qui comprennent d'autres antigènes de la coqueluche et notamment une toxine de la coqueluche ou l'une de ses anatoxines, la protéine 69 kDa et l'hémagglutinine filamenteuse ainsi que d'autres antigènes de <u>Bordetella</u>. De tels vaccins confèrent une protection à au moins 70 % des individus d'une population à risque.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Acellular pertussis vaccines and methods of preparation thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acellular pertussis vaccines and methods of preparation thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acellular pertussis vaccines and methods of preparation thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1783759

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.