Acellular pertussis vaccines and methods of preparation thereof

A - Human Necessities – 61 – K

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Details

A61K 39/10 (2006.01) A61K 39/116 (2006.01) A61P 31/04 (2006.01) C07K 14/235 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2220048

A cellular pertussis vaccines comprise purified toxin or toxoid thereof, filamentous haemagglutinin, pertactin and fimbrial agglutinogens formulated to confer protection to at least 70 % of members of an at-risk population. The fimbrial agglutinogens may be prepared from a Bordetella strain, particularly a B. pertussis strain by a multiple step procedure involving extraction of the fimbrial agglutinogens from cell paste and concentrating and purifying the extracted material.

La présente invention concerne des vaccins anticoquelucheux acellulaires qui comprennent une toxine purifiée ou l'une de ses anatoxines; de l'hémagglutinine filamenteuse, de la pertactine et des agglutinogènes fimbriés formulés de façon à conférer une protection à au moins 70 % des individus d'une population à risque. Ces agglutinogènes fimbriés peuvent se préparer à partir d'une souche Bordetella, et plus particulièrement d'une souche Bordetella pertussis, selon une procédure comportant plusieurs étapes et notamment l'extraction des agglutinogènes fimbriés à partir d'une pâte cellulaire, puis la concentration et la purification du matériau extrait.

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