C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 335/20 (2006.01) A61K 31/17 (2006.01) A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61K 31/445 (2006.01) C07C 335/22 (2006.01) C07D 207/09 (2006.01) C07D 207/14 (2006.01) C07D 211/58 (2006.01) C07D 261/08 (2006.01) C07D 261/10 (2006.01)
Patent
CA 2350899
Compounds of formula (I) wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6, -COR6, -OR6, -SR6, - SOR6, -SO2R6, -CONR7R8, -NR6N(R7R8), -N(R7R8) or W-Y-(CH2)n-Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be taken together to form aryl of 5 to 7 carbon atoms; G is alkyl of 1 to 6 carbon atoms; X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or pharmaceutical salts thereof, are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
La présente invention concerne des composés représentés par la formule générale (I) ou certains de leurs sels pharmaceutiques. Dans cette formule R¿1?-R¿5? sont indépendamment hydrogène, C¿1?-C¿6? alkyle, C¿2?-C¿6? alcényle, C¿2?-C¿6? alkynyle, C¿1?-C¿6? perhaloalkyle, C¿3?-C¿10? cycloalkyle, hétérocycloalkyle portant 3 à 10 éléments carbonés, aryle, hétéroaryle, halogène, -CN, -NO¿2?, -CO¿2?R¿6?, -COR¿6?, -OR¿6?, -SR¿6?, -SOR¿6?, -SO¿2?R¿6?, -CONR¿7?R¿8?, -NR¿6?N(R¿7?R¿8?), -N(R¿7?R¿8?) ou W-Y-(CH¿2?)¿n?-Z sous la réserve que l'un de R¿1?-R¿5? ne soit pas hydrogène; ou R¿2? et R¿3? ou R¿3? et R¿4?, forment ensemble un hétérocycloalkyle de 3 à 7 segments ou un hétéroaryle de 3 à 7 segments; R¿6? et R¿7? sont indépendamment hydrogène, C¿1?-C¿6? alkyle, C¿1?-C¿6? perhaloalkyle, ou aryle; R¿8? est hydrogène, C¿1?-C¿6? alkyle, C¿1?-C¿6? perhaloalkyle, C¿3?-C¿10? cycloalkyle, hétérocycloalkyle de 3 à 10 segments, aryle ou hétéroaryle, ou R¿7? et R¿8? peuvent former ensemble un hétérocycloalkyle de 3 à 7 segments; R¿9?-R¿12? sont indépendamment hydrogène, C¿1?-C¿4? alkyle, C¿1?-C¿4? perhaloalkyle, halogène, C¿1?-C¿4? alcoxy ou cyano, ou R¿9? et R¿10? ou R¿11? et R¿12? peuvent former ensemble un C¿5?-C¿7? aryle; W est O, NR¿6?, ou est absent; Y est -(CO)- ou -(CO¿2?)-, ou est absent; Z est C¿1?-C¿4? alkyle, -CN, -CO¿2?R¿6?, COR¿6?, -CONR¿7?R¿8?, -OCOR¿6?, -NR¿6?COR¿7?, -OCONR¿6?, -OR¿6?, -SR¿6?, -SOR¿6?, -SO¿2?R¿6?, SR6N(R7R8), -N(R¿7?R¿8?) ou phényle; G est C¿1?-C¿6? alkyle; X est une liaison, -NH, C¿1?-C¿6? alkyle, C¿1?-C¿6? alcényle, C¿1?-C¿6? alcoxy, C¿1?-C¿6? thioalkyle, C¿1?-C¿6? alkylamino, ou (CH)J; J est C¿1?-C¿6? alkyle, C¿3?-C¿7? cycloalkyle, phényle ou benzyle; et n est un entier valant de 1 à 6. Ces composés conviennent au traitement d'affections associées aux virus de l'herpès, y-compris le cytomégalovirus humain, les herpès simplex, le virus d'Epstein-Barr, le virus de la varicelle-zona, les herpèsvirus 6 et 7 humain et l'herpèsvirus de Kaposi.
Bloom Jonathan David
Digrandi Martin Joseph
Dushin Russell George
Lang Stanley Albert
O'hara Bryan Mark
American Home Products Corporation
Smart & Biggar
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