Acetamide derivatives as glucokinase activators, their...

C - Chemistry – Metallurgy – 07 – D

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C07D 277/46 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 3/00 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2700783

Acetamide derivative compounds of formula (I), their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.

La présente invention concerne des composés dérivés acétamide de formule (I), leurs stéréoisomères, tautomères, promédicaments, sels pharmaceutiquement acceptables, polymorphes, solvates et formulations de ceux-ci pour la prophylaxie, la gestion, le traitement, le contrôle de la progression, ou le traitement adjoint de maladies et/ou de conditions médicales où l'activation de la glucokinase pourrait être bénéfique. L'invention concerne également un procédé de préparation de ces dérivés acétamide.

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