Acetanilide derivatives

Details Acetanilide derivatives Acetanilide derivatives

C - Chemistry, Metallurgy

07

D

C07D 409/04 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/41 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 407/04 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 411/04 (2006.01) C07D 411/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2113913

A B S T R A C T ACETANILIDE DERIVATIVES The invention concerns acetanilide derivatives of the formula I Image I wherein R4 is (1-4C)alkyl; R5 is hydrogen or (1-4C)alkyl; Ar1 is phenylene, pyridinediyl or pyrimidinediyl; A1 is a direct link to X1 or A1 is (1-4C)alkylene; X1 is oxy, thio, sulphinyl or sulphonyl; Ar2 is thiophenediyl, furandiyl, thiazolediyl, oxazolediyl, thiadiazolediyl or oxadiazolediyl; R1 and R2 together form a group of the formula -A2-X2-A3- which together with the oxygen atom to which A2 is attached and with the carbon atom to which A3 is attached define a ring having 5 or 6 ring atoms, wherein each of A2 and A3 is (1-3C)alkylene and X2 is oxy, thio, sulphinyl or sulphonyl and which ring may bear one, two or three (1-4C)alkyl substituents; and R3 is (1-4C)alkyl; or pharmaceutically-acceptable salts thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.

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