Acethylcholinesterase(ache) variants of the n-terminus

Details Acethylcholinesterase(ache) variants of the n-terminus Acethylcholinesterase(ache) variants of the n-terminus

C - Chemistry, Metallurgy

12

N

C12N 9/18 (2006.01) C07K 16/40 (2006.01)

Patent

CA 2562567

A novel form of acetylcholinesterase (AChE) is provided, N-AChE, which bears a transmembrane domain. Exons encoding this novel form, the peptide comprising the transmembrane domain, as well as antibodies which recognize this novel form are also provided. N-AChE expression in the hippocampus is correlated with Alzheimer's disease, and its detection using the anti-N-AChE antibodies may be a new diagnostic method for this disease.

L'invention concerne une nouvelle forme d'acétylcholinestérase (AChE), N-AChE, qui porte un domaine transmembranaire. L'invention concerne également des exons codant cette nouvelle forme, le peptide comprenant le domaine transmembranaire, ainsi que des anticorps qui reconnaissent ladite nouvelle forme. L'expression N-AChE chez l'hippocampe est corrélée à la maladie d'Alzheimer et sa détection à l'aide d'anticorps anti-N-AChE peut constituer un nouveau procédé de diagnostic de cette maladie.

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