Acetic acid derivatives pharmacological activity and...

Details Acetic acid derivatives pharmacological activity and... Acetic acid derivatives pharmacological activity and...

A - Human Necessities

61

K

167/263

A61K 31/19 (2006.01) C07C 29/09 (2006.01) C07C 29/60 (2006.01) C07C 51/16 (2006.01) C07C 51/36 (2006.01) C07C 51/367 (2006.01) C07C 51/377 (2006.01) C07C 51/41 (2006.01) C07C 53/126 (2006.01) C07C 57/03 (2006.01) C07C 59/01 (2006.01)

Patent

CA 1041015

ABSTRACT OF THE DISCLOSURE Acetic acid derivatives having the general formula: Image (I) and their pharmaceutically acceptable alkali metal salts, wherein R represents a radical of the formula: Image or Image in which R1 and R2 are the same or different and each represent an alkyl radical having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or a methyl radical and n is an integer in the range of from 0 to 3 inclusive. These compounds exhibit a competitive inhibitory activity with respect to ?-aminobutyric .alpha.-ketoglutaric transaminase and antianoxic and anticonvulsant actions and can thus be utilized for the treatment of central neurological dis- orders whether resulting or not from cerebral ischemia.

229907

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