Acetohydroxamic acid compound, pharmaceutical compositions...

Details Acetohydroxamic acid compound, pharmaceutical compositions... Acetohydroxamic acid compound, pharmaceutical compositions...

C - Chemistry, Metallurgy

07

D

C07D 333/24 (2006.01) A61K 31/38 (2006.01) A61K 31/70 (2006.01) C07D 333/20 (2006.01) C08B 37/00 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2070492

Abstract The acetohydroxamic acid compound of formula I Image as such or in form of a complex with .beta.-cyclodextrin or hy- droxypropyl-.beta.-cyclodextrin specifically inhibits 5-lipoxy- qenase and is useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leukotrienes. The acetohydroxamic acid compound may be prepared by reacting 3-thiophenecarboxaldehyde with hydro- xylamine or a salt thereof to form the corresponding oxime, reducing the oxime with a boron containing reducing agent to form N (thien-3-yl)methyl-hydroxylamine and in- troducing the acetyl residue.

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