Acetophenone potentiators of metabotropic glutamate receptors

Details Acetophenone potentiators of metabotropic glutamate receptors Acetophenone potentiators of metabotropic glutamate receptors

C - Chemistry, Metallurgy

07

D

C07D 257/04 (2006.01) A61K 31/166 (2006.01) A61K 31/18 (2006.01) A61K 31/192 (2006.01) A61K 31/41 (2006.01) A61P 25/00 (2006.01) C07C 63/06 (2006.01) C07C 233/92 (2006.01) C07C 311/51 (2006.01)

Patent

CA 2495756

The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

La présente invention concerne des composés qui sont des potentialisateurs des récepteurs métabotropiques du glutamate, parmi lesquels le récepteur mGluR2, et qui sont utilisés pour le traitement ou la prévention de troubles neurologiques et psychiatriques associés au dysfonctionnement du glutamate, et de maladies dans lesquelles les récepteurs métabotropiques du glutamate sont impliqués. La présente invention concerne également des compositions pharmaceutiques comprenant ces composés. L'invention concerne également l'utilisation de ces composés et de ces compositions pour prévenir ou traiter des maladies dans lesquelles les récepteurs métabotropiques du glutamate sont impliqués.

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