Acetyl 2-hydroxy-1,3 diaminoalkanes

Details Acetyl 2-hydroxy-1,3 diaminoalkanes Acetyl 2-hydroxy-1,3 diaminoalkanes

C - Chemistry, Metallurgy

07

D

C07D 335/04 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/21 (2006.01) A61K 31/38 (2006.01) A61K 31/425 (2006.01) A61K 31/472 (2006.01) A61P 25/28 (2006.01) C07C 233/36 (2006.01) C07C 235/10 (2006.01) C07C 235/74 (2006.01) C07C 237/04 (2006.01) C07C 237/20 (2006.01) C07C 271/24 (2006.01) C07C 311/05 (2006.01) C07C 327/30 (2006.01) C07D 215/04 (2006.01) C07D 237/14 (2006.01) C07D 263/02 (2006.01) C07D 279/16 (2006.01) C07D 311/04 (2006.01) C07D 333/20 (2006.01)

Patent

CA 2498248

Disclosed are compounds of the formula: (I) where variables Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.

L'invention concerne des composés de la formule (I) dans laquelle les variables Z, X, R¿15?, R¿2?, R¿3?, et R¿c? ont la notation définie dans la description. Les composés ici décrits sont des inhibiteurs de l'enzyme .alpha. secrétase et ils sont par conséquent utiles dans le traitement de la maladie d'Alzheimer ainsi que d'autres maladies caractérisées par le dépôt du peptide bêta A chez un mammifère.

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