A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/221 (2006.01) A61K 31/205 (2006.01) A61K 31/475 (2006.01) A61K 31/555 (2006.01) A61K 45/06 (2006.01) A61P 25/02 (2006.01)
Patent
CA 2505937
This invention disclosed the use of acetyl L-carnitine or of a pharmaceutically acceptable salt thereof for the preparation of a medicament for preventing and/or treating peripheral neuropathies induced by the administration of a peripheral neuropathy-inducing anticancer agent. In particular said anticancer agent is selected from the group consisting of the family of platin compounds, taxanes, epothilone class and vinca alkaloids, farnesyl transferase inhibitors, thalidomide, 5-fluorouracil, cryptophycin analogues, proteasome inhibitors. Said medicament can be administered in a co- ordinated manner to a subject suffering from said peripheral neuropathies, or expected to suffer from said peripheral neuropathies. Beneficial effects on the patient~s quality of life are achieved and an improvement of therapeutic index of the anticancer agent is obtained.
L'invention concerne l'utilisation d'acétyle L-carnitine ou d'un sel de ce composé pharmaceutiquement acceptable pour la préparation d'un médicament permettant de prévenir et/ou traiter des neuropathies périphériques induites par administration d'un agent anticancéreux à induction de neuropathie périphérique. Plus particulièrement, cet agent anticancéreux est choisi dans le groupe de la famille composés de platine, taxanes, alcaloïdes vinca et de la classe épothilone, inhibiteurs de farnesyl transférase, thalidomide, 5-fluorouracil, analogues de cryptophycine, inhibiteurs de proteasome. Ce médicament peut être administré de manière coordonnée à un sujet souffrant de ces neuropathies périphériques, ou risquant de souffrir desdites neuropathies périphériques. Des effets bénéfiques sur la qualité de vie du patient sont obtenus ainsi qu'une amélioration de l'indice thérapeutique de l'agent anticancéreux.
Cavazza Claudio
Pisano Claudio
Vesci Loredana
Fetherstonhaugh & Co.
Sigma-Tau Industrie Farmaceutiche Riunite Spa
LandOfFree
Acetyl-l-carnitine for the prevention and/or treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Acetyl-l-carnitine for the prevention and/or treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acetyl-l-carnitine for the prevention and/or treatment of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1995340