Acetyl pyrrolidinyl indole derivative

Details Acetyl pyrrolidinyl indole derivative Acetyl pyrrolidinyl indole derivative

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/497 (2006.01) A61K 45/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 25/02 (2006.01) A61P 27/02 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2733646

The present invention relates to compounds, which are useful for treatment and/or prevention of diabetes mellitus, diabetes mellitus complications or obesity, since the compounds have glucokinase-activating effects, and are presented in Formula (I): wherein R1 represents a lower alkylsulfonyl group; R2 represents a hydrogen atom; R20 represents, e.g., a hydrogen atom; m represents an integer of from 1 to 3; and n represents zero or 1, or relates to a pharmaceutically acceptable salts thereof.

La présente invention concerne des composés, qui sont utiles dans le traitement et/ou la prévention du diabète sucré, des complications du diabète sucré ou de l'obésité, les composés ayant des effets d'activation de la glucokinase, et qui sont présentés dans la formule (I) : dans laquelle R1 représente un groupe alkylsulfonyle de faible poids moléculaire; R2 représente un atome dhydrogène; R20 représente, par exemple, un atome d'hydrogène; m représente un entier allant de 1 à 3; et n représente zéro ou 1. L'invention concerne également des sels pharmaceutiquement acceptables de ceux-ci.

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