A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 47/18 (2006.01)
Patent
CA 2619441
This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents, such as EDTA. Further, this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are useful in the treatment of acetaminophen overdose, acute liver failure, various cancers, methacrylonitrile poisoning, reperfusion injury during cardio bypass surgery, and radiocontrast-induced nephropathy, and can also be used as a mucolytic agent.
L'invention porte sur de nouvelles compositions d'acétylcystéine en solution, sensiblement exemptes d'agents chélateurs métalliques tels que l'EDTA. L'invention porte également sur les méthodes d'utilisation de ces compositions. Lesdites compositions et méthodes, qui ont pour objectif d'améliorer la tolérance et la compatibilité et de maintenir la stabilité de la préparation pharmaceutique, s'avèrent utiles pour le traitement: de l'overdose d'acétaminophène, de l'insuffisance hépatique aiguë, de différents cancers, de l'empoisonnement par le méthacrylonitrile, des traumatismes de reperfusion lors de pontages cardiaques, et des néphropathies dues aux produits de contraste radiologiques. Elles peuvent également servir d'agents mucolytiques.
Pavliv Leo
Cumberland Pharmaceuticals Inc.
Kirby Eades Gale Baker
LandOfFree
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