Acetylene derivatives having lipoxygenase inhibitory activity

C - Chemistry – Metallurgy – 07 – C

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C07C 275/64 (2006.01) A61K 31/17 (2006.01) A61K 31/33 (2006.01) C07C 323/47 (2006.01) C07D 213/40 (2006.01) C07D 213/64 (2006.01) C07D 213/643 (2006.01) C07D 213/65 (2006.01) C07D 213/68 (2006.01) C07D 213/69 (2006.01) C07D 215/227 (2006.01) C07D 217/24 (2006.01) C07D 239/34 (2006.01) C07D 241/18 (2006.01) C07D 263/56 (2006.01) C07D 263/58 (2006.01) C07D 277/34 (2006.01) C07D 307/52 (2006.01) C07D 307/56 (2006.01) C07D 307/58 (2006.01) C07D 307/64 (2006.01) C07D 307/81 (2006.01) C07D 333/20 (2006.01) C07D 3

Patent

CA 2087836

2087836 9201682 PCTABS00010 Compounds of the structure (I) where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is alkyl, cycloalkyl or -NR1R2, where R1 and R2 are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted carbocyclic aryl, furyl, benzol[b]furyl, thienyl, or benzol[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

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