C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 275/64 (2006.01) A61K 31/17 (2006.01) A61K 31/33 (2006.01) C07C 323/47 (2006.01) C07D 213/40 (2006.01) C07D 213/64 (2006.01) C07D 213/643 (2006.01) C07D 213/65 (2006.01) C07D 213/68 (2006.01) C07D 213/69 (2006.01) C07D 215/227 (2006.01) C07D 217/24 (2006.01) C07D 239/34 (2006.01) C07D 241/18 (2006.01) C07D 263/56 (2006.01) C07D 263/58 (2006.01) C07D 277/34 (2006.01) C07D 307/52 (2006.01) C07D 307/56 (2006.01) C07D 307/58 (2006.01) C07D 307/64 (2006.01) C07D 307/81 (2006.01) C07D 333/20 (2006.01) C07D 3
Patent
CA 2087836
2087836 9201682 PCTABS00010 Compounds of the structure (I) where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is alkyl, cycloalkyl or -NR1R2, where R1 and R2 are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted carbocyclic aryl, furyl, benzol[b]furyl, thienyl, or benzol[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
Basha Anwer
Bhatia Pramila A.
Brooks Dee W.
Kerkman Daniel J.
Martin Jonathan G.
Abbott Laboratories
Goudreau Gage Dubuc
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