Acetylene derivatives of amino acids

Details Acetylene derivatives of amino acids Acetylene derivatives of amino acids

C - Chemistry, Metallurgy

07

F

260/324, 260/468

C07F 7/08 (2006.01)

Patent

CA 1080715

Abstract of the Disclosure Novel compounds of the following general formula are useful pharmacologic agents: Image R is selected from hydrogen, alkylcarbonyl wherein the alkyl moiety contains from 1 to 4 carbon atoms, alkoxy- carbonyl wherein the alkoxy moiety contains from 1 to 4 carbon atoms and may be straight or branched, and Image wherein R10 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl and p-hydroxybenzyl; R2 is selected from hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, a lower alkylamino group wherein the alkyl moiety contains from 1 to 4 carbon atoms, and Image wherein R4 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl, and p-hydroxybenzyl; [A] is selected from Image and -CH=CH- wherein R1 is selected from hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyland substituted phenyl wherein the substiteuents on the substituted phenyl may be attached at the ortho, meta or para positions of the phenyl ring and are selected from halogen, lower alkoxy of from 1 to 4 carbon atoms, and lower alkyl of from 1 to 4 carbon atoms; n is an integer of from 1 to 5; and the lactams of said compounds wherein [A] represents Image ; R and R1 represent hydrogen and n is the integer 2 or 3; and pharmaceutically acceptable salts and individual optical isomers thereof.

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