Acetylenes disubstituted with a 5 or 8 substituted...

Details Acetylenes disubstituted with a 5 or 8 substituted... Acetylenes disubstituted with a 5 or 8 substituted...

C - Chemistry, Metallurgy

07

C

C07C 69/76 (2006.01) A61K 31/19 (2006.01) A61K 31/235 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) A61K 31/695 (2006.01) C07C 17/10 (2006.01) C07C 17/26 (2006.01) C07C 17/35 (2006.01) C07C 45/28 (2006.01) C07C 45/67 (2006.01) C07C 45/68 (2006.01) C07C 49/697 (2006.01) C07C 63/49 (2006.01) C07C 63/66 (2006.01) C07C 65/28 (2006.01) C07C 65/38 (2006.01) C07C 229/46 (2006.01) C07C 233/58 (2006.01) C07C 251/44 (2006.01) C07C 251/48 (2006.01) C07C 255/41 (2006.01) C07C 255/47 (2006.01) C07C 309/65 (2006.0

Patent

CA 2208844

Acetylenes substituted with a phenyl or heteroaryl group and with a 5,6,7,8- tetrahydronaphthyl or 7,8-dihydronaphthyl group have retinoid-like biological activity. The 5,6,7,8-tetrahydronaphthyl or 7,8-dihydronaphthyl group is substituted in the 5 position.

Des acétylènes substitués par un groupe phényle ou hétéroaryle et par un groupe 5,6,7,8-tétrahydronaphtyle ou 7,8-dihydronaphtyle ont une activité biologique analogue aux rétinoïdes. Le groupe substituant 5,6,7,8-tétrahydronaphtyle ou 7,8-dihydronaphtyle est situé en position 5.

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