Acetylenes disubstituted with a heteroaromatic group and a...

Details Acetylenes disubstituted with a heteroaromatic group and a... Acetylenes disubstituted with a heteroaromatic group and a...

C - Chemistry, Metallurgy

07

D

167/207, 260/251

C07D 213/54 (2006.01) C07D 213/78 (2006.01) C07D 213/80 (2006.01) C07D 239/24 (2006.01)

Patent

CA 1311757

ABSTRACT Retinoid-like activity is exhibited by compounds of the formula Image where R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, -COOH or an ester or amide thereof, -CH2OH or an ether or ester derivative thereof, or -CHO or an acetal derivative thereof, or -CORl or a ketal derivative thereof where R1 is -(CH2)mCH3 where m is 0-4; or a pharmaceutically acceptable salt thereof.

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