C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/207, 260/250
C07D 213/80 (2006.01) A61K 31/33 (2006.01) C07D 213/55 (2006.01) C07D 237/08 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01)
Patent
CA 2031480
Retinoid like activity is exhibited by compounds of the formula <SEE FORMULA> where R1-R3 independently are hydrogen, lower alkyl, cycloalkyl or lower alkenyl, A and B independently are hydrogen, lower alkyl, cycloalkyl, lower alkenyl, 8R~ or OR~ where R~ is lower alkyl, cycloalkyl or lower alkenyl; Y is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl or oxazolyl; E is lower alkenyl, lower alkynyl, lower cycloalkyl, lower branched chain alkyl or (CH2)n where n is 0- 6; and Z is H, OH, OR', OCOR', -COON or a pharmaceutically acceptable salt, ester or amide thereof , -CH2OH or an ether or ester derivative, or -CHO or an acetal derivative, or -COR' or a ketal derivative where R~ is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons.
Allergan Inc.
Chandraratna Roshantha A. S.
Gowling Lafleur Henderson Llp
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