Acetylenic .alpha.-amino acid-based sulfonamide hydroxamic...

Details Acetylenic .alpha.-amino acid-based sulfonamide hydroxamic... Acetylenic .alpha.-amino acid-based sulfonamide hydroxamic...

C - Chemistry, Metallurgy

07

C

C07C 311/29 (2006.01) C07C 311/39 (2006.01) C07C 311/47 (2006.01) C07C 311/64 (2006.01) C07D 207/12 (2006.01) C07D 207/16 (2006.01) C07D 207/27 (2006.01) C07D 209/20 (2006.01) C07D 211/66 (2006.01) C07D 213/32 (2006.01) C07D 213/42 (2006.01) C07D 213/70 (2006.01) C07D 213/71 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 215/48 (2006.01) C07D 217/26 (2006.01) C07D 235/06 (2006.01) C07D 241/04 (2006.01) C07D 243/08 (2006.01) C07D 261/18 (2006.01) C07D 265/30 (2006.01) C07D 277/06 (2006.01) C07D 2

Patent

CA 2356299

Compound of the formula (B) are useful in treating disease conditions mediated by TNF-.alpha., such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

Cette invention concerne des composés correspondant à la formule (B) qui sont utiles dans le traitement d'états maladifs induits par le facteur de nécrose tumorale .alpha., tels que l'arthrite rhumatoïde, l'arthrose, la septicémie, le SIDA, la colite ulcéreuse, la sclérose multiple, la maladie de Crohn et la perte de cartilage dégénérative.

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