C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/29 (2006.01) A61K 31/18 (2006.01) A61K 31/664 (2006.01) A61P 19/02 (2006.01) C07C 309/42 (2006.01) C07C 309/87 (2006.01) C07F 9/53 (2006.01)
Patent
CA 2356345
The invention discloses hydroxamide acids of formula (B) which are useful in treating disease conditions mediated by TNF-.alpha., such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss. In the above formula, the dotted line represents an optional double bond, and R5, R6, R7, R8, R11, R12, X, Y and Z have the meanings given in the specification.
La présente invention concerne des acides hydroxamides représentés par la formule générale (B) convenant au traitement de pathologies à médiation des TNF-.alpha., et notamment la polyarthrite rhumatoïde, l'arthrose, la septicémie, le SIDA, la colite ulcéreuse, la sclérose en plaques, la maladie de Crohn et la dégénérescence des cartilages. Dans cette formule, les lignes en pointillés représentent une liaison double facultative. En outre, R¿5?, R¿6?, R¿7?, R¿8?, R¿11?, R¿12?, X, Y et Z sont tels que spécifiés dans la description.
Chen James Ming
Levin Jeremy Ian
Zask Arie
American Cyanamid Company
Torys Llp
Wyeth Holdings Corporation
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