Acetylenic ortho-sulfonamido and phosphinic acid amido...

Details Acetylenic ortho-sulfonamido and phosphinic acid amido... Acetylenic ortho-sulfonamido and phosphinic acid amido...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/47 (2006.01) A61P 19/02 (2006.01) A61P 37/00 (2006.01) C07C 309/42 (2006.01) C07C 309/87 (2006.01) C07D 215/54 (2006.01) C07D 221/00 (2006.01) C07D 231/00 (2006.01) C07D 261/00 (2006.01) C07D 275/00 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07F 9/53 (2006.01)

Patent

CA 2355735

Compounds of formulas (a), (b), (c), or (d) are provided wherein P and Q are (e) or (f), provided that when P is (e), Q is (f), and vice versa; which are useful in disease conditions mediated by TNF-.alpha., such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

L'invention se rapporte à des composés représentés par les formules (a), (b), (c) ou (d) dans lesquelles P et Q sont (e) ou (f), à condition que lorsque P est (e), Q est (f) et inversement. Ces composés s'avèrent utiles pour le traitement des états pathologiques dont la médiation est assurée par le TNF-.alpha., tels que la polyarthrite rhumatoïde, l'arthrose, les septicémies, le SIDA, la recto-colite ulcéro-hémorragique, la sclérose en plaques, la maladie de Crohn et les pertes cartilagineuses dégénératives.

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