Acetylenic piperazines as metabotropic glutamate receptor...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 1/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2616318

The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, A, B, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses of, and processes of making the compounds, as well as methods of medical treatment of mGluR 5 mediated disorders.

L'invention concerne des composés de formule (I) ou des sels ou des solvates pharmaceutiquement acceptables de ceux-ci. Dans cette formule, Ar1, A, B, R1, m et n sont définis dans la description. L'invention concerne également des compositions pharmaceutiques et leurs utilisations, ainsi que des procédés de fabrication de ces composés, et des méthodes de traitement médical de troubles médiés par mGluR5.

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