C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/49 (2006.01) A61K 31/18 (2006.01) A61K 31/5375 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/18 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01) C07C 309/42 (2006.01) C07C 309/87 (2006.01) C07C 319/02 (2006.01) C07C 327/06 (2006.01) C07C 327/46 (2006.01) C07D 295/12 (2006.01) C07F 9/53 (2006.01) C07B 53/00 (2006.01)
Patent
CA 2356480
Compounds of formula (B): (1a), or (1b), (1c) are provided wherein the variables are as defined herein which are useful in disease conditions mediated by TNF-.alpha., such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
L'invention se rapporte à des composés représentés par les formules (B): (1a), (1b) ou (1c) dans lesquelles les variables utilisées sont définies dans la description associée. Ces composés s'avèrent utiles pour le traitement des états pathologiques dont la médiation est assurée par le TNF-.alpha., tels que la polyarthrite rhumatoïde, l'arthrose, les septicémies, le SIDA, la recto-colite ulcéro-hémorragique, la sclérose en plaques, la maladie de Crohn et les pertes cartilagineuses dégénératives.
Chen James Ming
Levin Jeremy Ian
American Cyanamid Company
Torys Llp
Wyeth Holdings Corporation
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