Ache antisense deoxyoligonucleotide as an anti-inflammatory...

A - Human Necessities – 61 – K

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A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2543305

The present invention provides a novel use for AChE antisense oligonucleotides as anti-inflammatory agents, wherein said oligonucleotides are preferably as denoted by SEQ. ID. NO:1, SEQ. ID. NO:2 and SEQ. ID. NO:7. Described are pharmaceutical compositions for the treatment of inflammatory conditions, as well as methods of treatment thereof, comprising as active agent said AChE antisense oligonucleotides.

L'invention concerne une nouvelle utilisation des oligonucléotides antisens AChE comme agents anti-inflammatoires; ces oligonucléotides correspondant préférablement aux séquences:SEQ. ID. NO:1, SEQ. ID. NO:2 et SEQ. ID. NO:7. L'invention décrit en outre des compositions pharmaceutiques destinées au traitement des états inflammatoires, ainsi que des méthodes de traitement de ces états, qui contiennent comme principe actif lesdits oligonucléotides antisens AChE.

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