Acid cleavable compounds, their preparation and use as...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/96 (2006.01) A61K 38/18 (2006.01) A61K 38/30 (2006.01) A61K 47/48 (2006.01) C07B 59/00 (2006.01) C07D 257/02 (2006.01) C07D 307/64 (2006.01) C07D 307/89 (2006.01) C07D 493/18 (2006.01) C07F 9/38 (2006.01) C07K 14/52 (2006.01) C07K 14/575 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2157402

Novel compounds, their preparation and their use as bifunctional acid-labile crosslinking agents which are cleavable in an acid environment at a pH of below about 5.0 allowing for the controlled release of nucleophilic groups attached thereto are disclosed.

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