Acid derivatives useful as serine protease inhibitors

Details Acid derivatives useful as serine protease inhibitors Acid derivatives useful as serine protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/155 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01) A61K 45/06 (2006.01) A61P 7/02 (2006.01) C07C 257/18 (2006.01) C07D 211/60 (2006.01) C07D 223/06 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2426716

Compounds of formula I and II, or pharmaceutically-acceptable salts thereof , are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B is phenyl or pyridyl, L is a linker, and R1 R27, W, Z1 , and Z2 are as defined in the specification.

L'invention porte sur des composés des formules (I) et (II), ou sur leurs sels acceptables d'un point de vue pharmaceutique. Ces composés sont utiles comme inhibiteurs des facteurs VIIa, IXa, Xa, FXIa, tryptase et urokinase, le noyau B étant un phényle ou un pyridyle, L étant un lieur et R¿1? - R¿27?, W, Z¿1?, et Z¿2? étant définis dans la demande.

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