Acid-labile linker molecules

Details Acid-labile linker molecules Acid-labile linker molecules

C - Chemistry, Metallurgy

07

K

C07K 17/02 (2006.01) A61K 47/48 (2006.01) C07D 307/34 (2006.01) C07D 307/60 (2006.01) C07D 493/10 (2006.01) C07D 493/20 (2006.01) C07H 15/252 (2006.01) C07H 19/01 (2006.01) C07H 21/00 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2058595

Abstract. This invention relates to the field of immune therapy of cancer, more specifically to immunoconjugates of a cytotoxic moiety with a targeting moiety, more specifically to immunoconjugates of antibodies or fragments or functional derivatives of antibodies coupled to a cytotoxic substance such as drugs, toxins or radioisotopes. It especially relates to the release of substances bound to a targeting moiety through the use of acid-cleavable linker molecules.

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