C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/103.33
C12N 9/72 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1300008
ABSTRACT A lyophilised pharmaceutical formulation of tissue plasminogen activator and a process for its pre- paration by vacuum drying a frozen aqueous solution thereof, in which the pH is from 2 to 5; the lyophilised formulation has improved solubility in aqueous solution as compared with prior lyophilised formulations of tissue plasminogen activator, and thus capable of producing a parenteral solution of high t-PA concentration without substantial risk of precipitation; such parenteral solutions of t-PA are useful in dissolving blood clots.
510097
Berger Henry
Johnston Michael D.
Berger Henry
Johnston Michael D.
Swabey Ogilvy Renault
Wellcome Foundation Limited (the)
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