Acoustical removal of particles from magnetic matrix

Details Acoustical removal of particles from magnetic matrix Acoustical removal of particles from magnetic matrix

B - Operations, Transporting

01

D

209/92

B01D 35/06 (2006.01) B03C 1/02 (2006.01)

Patent

CA 1285247

ABSTRACT OF THE DISCLOSURE An apparatus for dislodging fragile particles, such as intact biological cells, retained by the separation matrix in a flow chamber of a magnetic separation system. The apparatus incorporates a piezoelectric transducer which is coupled to the matrix and an associated drive circuit. The system can operate in a capture phase, whereby fragile particles are selectively captured from a carrier fluid passing through the matrix, with those captured particles being magnetically held in place within the matrix. In the elutriation phase, an elutriation fluid is passed through the matrix and the drive circuit excites the piezoelectric transducer. In response to the excitation, the transducer establishes acoustic waves in the elutriation fluid passing through the matrix, vibrating the matrix itself. The acoustic waves can be ultrasonic. The acoustic waves and matrix vibration operate to dislodge the intact cells from the matrix, even at relatively low elutriation flow rates.

536817

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