C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/277
C07D 417/12 (2006.01) A61K 31/47 (2006.01) C07D 219/06 (2006.01) C07D 219/10 (2006.01) C07D 417/14 (2006.01)
Patent
CA 1258854
Abstract The present invention is concerned with acridanone derivatives of the general formula Image I wherein the dotted line signifies an optional bond, R1 signifies hydrogen, halogen or nitro, R2 signifies hydrogen or lower alkyl, one of the substituents R3 and R4 signifies hydrogen or lower alkyl and the other together with R sig- nifies an additional bond, A signifies lower alkylene, R5 signifies a 5-membered nitrogen-containing, optionally lower alkyl-substituted aromatic heterocycle, amino or the group Image the symbol ? signifies a 5- or 6-membered, optionally lower alkyl-substituted saturated - ii - heterocycle which can contain as a ring member an oxygen or sulphur atom or the group ?NH or ?N(B)n-A1-R6, B signifies the group -CO-, -COO- or -SO2-, n signifies the number 0 or 1, A1 signifies lower alkylene, R6 signifies hydrogen, amino, lower alkylamino or di(lower alkyl)amino and R7 signifies hydrogen or lower alkyl, and pharmaceutically acceptable acid addition salts thereof, their manufacture and pharmaceutical preparations based thereon. These novel substances possess valuable pharmacological properties and can be used in the control or prevention of illnesses. In particular, they display valuable schistosomicidal activities and can accordingly be used in the control or prevention of schistosomiasis.
440203
Brombacher Urs
Link Helmut
Montavon Marc
Gowling Lafleur Henderson Llp
Hoffmann-La Roche(f.) & Co. Aktiengesellschaft
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