C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/06 (2006.01) A61K 31/47 (2006.01) A61K 31/473 (2006.01) A61K 31/495 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2250863
The present invention relates to several novel acridone-derived compounds of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as Human Immunodeficiency Virus. In addition, these compounds are anti-neoplastic agents useful in the treatment of various forms of cancer. In said formula (I) or (II) R1 and R2 are independently -H, -OH, amino, alkylamino, dialkylamino, alkoxy, alkyl, haloalkyl or halogen; n is 2 to 6, X and X' are independently -N or -NO2; Y and Y' are independently -N or -CH, or -H; and the double-stash represents a double bond or no bond.
La présente invention concerne plusieurs nouveaux composés dérivés de l'acridone, de formule (I) ou (II), qui sont de puissants agents antiviraux, utiles dans le traitement de maladies virales, telles que celle due au virus de l'immunodéficience humaine. De plus, ces composés sont des agents antinéoplasiques utiles dans le traitement de diverses formes de cancer. Dans lesdites formules, R1 et R2 sont indépendamment -H, -OH, amino, alkylamino, dialkylamino, alcoxy, alkyle, haloalkyle ou halogène; n est 2 à 6; X et X' sont indépendamment -N ou -NO2; Y et Y' sont indépendamment -N ou -CH, ou -H; et la double barre oblique représente une double liaison ou pas de liaison du tout.
Cholody Marek W.
Michejda Christopher J.
Rice William G.
Turpin James A.
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Smart & Biggar
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