Acridone-derived compounds useful as antiretroviral agents

A - Human Necessities – 61 – K

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A61K 31/4745 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2525550

Viral replication inhibiting compounds of the general formula (II): (see formula I) wherein R is H, C1-C8 alkyl or a grouping which makes the composition function as a prodrug; R1 and R2 are independently -H, -OH, amino, C1-C8 alkylamino, C1-C8 dialkylamino, C1-C8 alkoxy, C1-C8 alkyl, C1-C8 haloalkyl or a halogen atom; n is 2 to 6; X and X' are independently -N or -NO2; Y and Y' are independently -N, -CH or -H; and each double dash represents a double bond or no bond, such that when X or X' is -N and Y or Y' is -CH or -N, the double dash is a double bond, and when X or X' is -N02 and Y or Y' is -H, the double dash is no bond.

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