Acrosomal sperm protein and uses thereof

Details Acrosomal sperm protein and uses thereof Acrosomal sperm protein and uses thereof

A - Human Necessities

61

K

A61K 39/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2328906

The present invention relates to an acrosomal sperm protein for use in immunocontraception of male and female subjects and as a marker for fertility. The present invention provides a method of immunocontraception of a male or female subject, which comprises administering an antigenic fragment of a P34 protein showing a high specificity for the P34 to the subject to elicit an immunocontraception response by the subject. An immune response against the peptide occurs without side effects. Probes and diagnosis kits for male or female infertility are also provided.

La présente invention concerne une protéine acrosomiale du sperme destinée à être utilisée en immunocontraception de sujets mâles et femelles et en tant que marqueur de fertilité. La présente invention concerne une méthode d'immunocontraception d'un sujet mâle ou femelle, laquelle consiste à administrer un fragment antigénique d'une protéine P34, présentant une grande spécificité pour la P34, au sujet afin de mettre en lumière une réponse d'immunocontraception chez le sujet. Une réponse immune contre le peptide se produit sans effet secondaire. L'invention concerne également des sondes et des nécessaires de diagnostic de l'infertilité mâle ou femelle.

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