Acrylamide derivatives and process for production thereof

Details Acrylamide derivatives and process for production thereof Acrylamide derivatives and process for production thereof

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07D 209/10 (2006.01) C07D 209/60 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2205872

An acrylamide derivative represented by general formula (1) e.g., methyl (S,S)- 3,3'-[3,3'-(1,4-phenylene-diacryloyl)]bis[1-chloromethyl-5-hydroxy-7- trifluoromethyl-1,2,3,6-tetrahydropyrrolo[3,2-e]-indole-8-carboxylate, having a high cancer cell selectivity, a low toxicity, and a potent activity against solid tumors.

Dérivé d'acrylamide représenté par la formule générale (1), tel que méthyle (S,S)-3,3'-[3,3'-(1,4-phénylène-diacryloyl)]bis[1-chlorométhyl-5-hydroxy-7-trifluorométhyl-1,2,3,6-tétrahydropyrrolo[3,2-e]-indole-8-carboxylate, à sélectivité élevée par rapport aux cellules cancéreuses, à faible toxicité et à activité puissante contre les tumeurs solides.

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