C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/38 (2006.01) C07C 235/36 (2006.01) C07C 323/41 (2006.01) C07D 209/08 (2006.01) C07D 211/22 (2006.01) C07D 211/46 (2006.01) C07D 213/30 (2006.01) C07D 213/32 (2006.01) C07D 213/38 (2006.01) C07D 213/68 (2006.01) C07D 213/75 (2006.01) C07D 231/12 (2006.01) C07D 231/56 (2006.01) C07D 233/60 (2006.01) C07D 295/135 (2006.01)
Patent
CA 2741433
Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R', R", W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.
L'invention porte sur des dérivés acrylamido utiles comme agents thérapeutiques, en particulier pour la prévention et/ou le traitement de maladies et affections associées à l'activité du pore de transition de perméabilité mitochondriale (MPTP), telles que les maladies caractérisées par une ischémie/reperfusion, un endommagement tissulaire oxydatif ou dégénératif. Ces composés sont représentés par la formule de structure (I) dans laquelle R, R', R'', W et a sont tels que définis dans la description. L'invention porte également sur la préparation de ces composés, ainsi que sur des compositions pharmaceutiques les contenant.
Ballarini Marco
Cappa Anna
Carenzi Giacomo
Fancelli Daniele
Minucci Saverio
Benoit & Cote Associes Inc.
Congenia S.r.l.
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