C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/179, 260/310
C07C 317/48 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/395 (2006.01) C07C 317/44 (2006.01) C07C 323/54 (2006.01) C07C 323/63 (2006.01) C07D 207/16 (2006.01) C07D 277/06 (2006.01) C07D 295/185 (2006.01) C07D 295/192 (2006.01)
Patent
CA 2021145
NOVEL ACRYLIC AMIDE DERIVATIVES, A PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPSITIONS CONTAINING THE SAME AND THEIR USE IN MEDICINE Abstract of the disclosure Novel acrylic amide derivative of the formula Image (I) wherein R1 represents a hydrogen or a halogen atom or a C1-4alkyl, a C1-4alkoxy or a nitro group. n is an integer of 0 to 2, A represents an amino acid residue derived from a naturally occuring amino acid or an antipode there- of which is connected to the acrylic acyl residue through its amino group; or a residue derived from thiazolidinecarboxylic acid connected to the acrylic acyl group through its nitrogen, or a derivative of the above residues wherein any free carboxy group is esterified with a C1-4alkyl group or is amidated; or A represents a group of formula Image (II) wherein R2 is a hydrogen atom or a phenyl, a C1-4alkyl or a C1-4alkoxycarbonyl group, and their salts which have interesting cytoprotective and antiulcer activities are provided. A process is also described for the preparation of said compounds.
Dobay Laszlo
Ezer Elemer
Fischer Janos
Fodor Tamas
Hajos Gyorgy
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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