C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) C07K 14/00 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C40B 30/04 (2006.01) C40B 40/10 (2006.01)
Patent
CA 2697032
The present disclosure provides activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM). The present disclosure provides activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM. Furthermore the present disclosure also provides ABPs which contain a first TBM, a second TBM and a CM. The ABPs exhibit an "activatable" conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. The disclosure further provides libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. The disclosure further provides ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
L'invention concerne des polypeptides de liaison activables (ABP), qui contiennent un groupe de liaison cible (TBM), un groupe de masquage (MM), et un groupe clivable (CM). La présente invention concerne des compositions d'anticorps activables, qui contiennent un TBM contenant un domaine de liaison d'antigène (ABD), un MM et un CM. En outre, la présente invention concerne également des ABP qui contiennent un premier TBM, un second TBM et un CM. Les ABP présentent une conformation "activable" de telle sorte qu'au moins un des TBM est moins accessible pour cibler lorsqu'il n'est pas clivé après clivage du CM en présence d'un agent de clivage qui peut cliver le CM. L'invention concerne en outre des bibliothèques d'ABP candidats, des procédés de dépistage pour identifier de tels ABP, et des procédés d'utilisation. L'invention concerne en outre des ABP ayant des TBM qui lient VEGF, CTLA-4, ou VCAM, des ABP ayant un premier TBM qui lie VEGF et un second TBM qui lie FGF, ainsi que des compositions et des procédés d'utilisation.
Daugherty Patrick Sean
Kamath Kathryn
Khare Sanjay
Stagliano Nancy E.
Thomas Jerry
Cytomx Therapeutics Llc
Smart & Biggar
The Regents Of The University Of California
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