Activatable fibrinolytic and anti-thrombotic proteins

Details Activatable fibrinolytic and anti-thrombotic proteins Activatable fibrinolytic and anti-thrombotic proteins

C - Chemistry, Metallurgy

12

N

C12N 9/68 (2006.01) C07K 7/64 (2006.01) C07K 14/315 (2006.01) C07K 14/815 (2006.01) C12N 9/48 (2006.01) C12N 9/72 (2006.01) C12N 15/62 (2006.01) C12N 15/81 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2069085

Proteinaceous compounds are activatable by enzymes of the clotting cascade to have fibrinolytic or clot formation inhibition activity. For example, a plasminogen analogue is activatable to plasmin by thrombin or Factor Xa. Fibrinolytic or clot formation inhibition activity is therefore directed to the site of clot formation.

Des composés protéiniques peuvent être activés par des enzymes de la cascade de coagulation de manière à exercer une activité fibrinolytique ou inhibitrice de coagulation. Par exemple, un analogue de plasminogène peut être activé pour former de la plasmine au moyen de la thrombine ou le facteur Xa. L'activité fibrinolytique ou inhibitrice de coagulation est donc dirigée au site de coagulation.

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