Activated cation channel of the osteoblast as a mechanism of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2354073

A transgenic non-human animal comprising a nucleotide construct capable of altered expression of the alpha-subunit of the epithelial sodium channel which is expressed at high levels in the osteoblast lineage, and compositions, constructs, cells and methods related thereto.

La présente invention concerne, d'une part un animal transgénique non humain comprenant une construction nucléotidique capable d'expression altérée de la sous-unité .alpha. du canal sodium épithélial s'exprimant à niveau élevé dans le lignage ostéoblastique, et d'autre part, des compositions, des constructions, des cellules et des procédés s'y rapportant.

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