Activated checkpoint therapy and methods of use thereof

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/382 (2006.01) A61K 31/337 (2006.01) A61K 31/352 (2006.01) A61K 31/38 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2492772

Disclosed herein are novel methods and compositions for Activated Checkpoint TherapyTM. Also disclosed are methods of treating cancer and apoptosis- associated disorders using cell cycle checkpoint activation modulators. The invention further discloses methods for screening for cell cycle checkpoint activation modulators and the cell cycle checkpoint activation modulators identified by those screening methods.

La présente invention a trait à de nouveaux procédés et composition la thérapie par l'activation de points de contrôle (Activated Checkpoint Therapy<SP>MD</SP>). L'invention a également trait à des procédés de traitement du cancer et de troubles liés à l'apoptose au moyen de modulateurs d'activation de points de contrôle de cycle cellulaire. L'invention a trait en outre à des procédés permettant le criblage pour des modulateurs d'activation de points de contrôle de cycle cellulaire et des modulateurs d'activation de points de contrôle de cycle cellulaire identifiés par lesdits procédés de criblage.

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