A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) C07D 207/46 (2006.01)
Patent
CA 2663375
Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND- HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.
La présente invention concerne des composés cytotoxiques activés destinés à se fixer à des molécules de ciblage, dans le traitement de maladies touchant des mammifères. Lesdits composés comprennent un activateur, un espaceur-lieur, un lieur (auto-immolant, par exemple), et un médicament cytotoxique choisi dans le groupe constitué des BENZYLSULFONES AMINO-SUBSTITUÉES (E)-2,6-DIALCOXYSTYRYLE 4-SUBSTITUÉES, des STYRYLSULFONANILIDES AMINO- ET HYDROXY-SUBSTITUÉS, et des DÉRIVÉS de PHÉNOXY- ET DE PHÉNYLTHIO-STYRYLSULFONE SUBSTITUÉES. Dans le cas des composés cytotoxiques activés fixés à la molécule de ciblage décrits ici, ladite molécule de ciblage est choisie dans le groupe constitué essentiellement d'un anticorps, d'un récepteur, d'un ligand, d'une cytokine, d'une hormone, et d'une molécule de transmission de signal. L'invention concerne en outre un procédé de traitement de maladies.
Bell Stanley C.
Cosenza Stephen
Duke Jodie
Fegley Glenn
Reddy E. Premkumar
Mbm Intellectual Property Law Llp
Onconova Therapeutics Inc.
LandOfFree
Activated cytotoxic compounds for attachment to targeting... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Activated cytotoxic compounds for attachment to targeting..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Activated cytotoxic compounds for attachment to targeting... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1706748