Activated her3 as a marker for predicting therapeutic efficacy

G - Physics – 01 – N

Patent

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G01N 33/574 (2006.01)

Patent

CA 2670522

The present invention provides methods for the determination of the activation level of Receptor Tyrosine kinases, e.g. phosporylated HER3, for the selection of patients for disease treatment. Methods are also provided for the evaluation of the biological and pharmacodynamic effects of an active substance and/or its efficacy in disease treatment, utilizing a tissue sample from a test subject, for example tumor material or normal tissue such as skin or hair follicle. Further, methods for the treatment of HER receptor-associated diseases are disclosed.

La présente invention se rapporte à des procédés pour la détermination de niveaux d'activation de récepteurs tyrosine kinases - HER3 phosporylé, par exemple - pour la sélection de patients en vue d'un traitement médical. La présente invention se rapporte également à des procédés pour l'évaluation des effets biologiques et pharmacodynamiques d'une substance active et/ou de son efficacité dans un traitement médical, au moyen d'un échantillon de tissu prélevé sur un sujet de test - une substance tumorale ou un tissu normal, comme de la peau ou un follicule pileux, par exemple. Par ailleurs, la présente invention se rapporte à des procédés pour le traitement de maladies associées à un récepteur HER.

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