Activated iododerivatives for the treatment of cancer and aids

Details Activated iododerivatives for the treatment of cancer and aids Activated iododerivatives for the treatment of cancer and aids

C - Chemistry, Metallurgy

07

C

C07C 233/78 (2006.01) A61K 31/165 (2006.01) A61K 31/35 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01) C07C 233/65 (2006.01) C07C 237/30 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 213/86 (2006.01) C07D 213/87 (2006.01) C07D 277/46 (2006.01) C07D 277/56 (2006.01) C07D 277/58 (2006.01) C07D 285/135 (2006.01) C07D 311/16 (2006.01)

Patent

CA 2286186

A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thio trapping group and an activating group. The presumptive mechanism of action in preventing cancer cell and virus replication is through inhibition of the binding of transcription factors to zinc finger binding domains. The compounds are effective in inhibiting growth of a variety of human and animal tumor and leukemia cell lines at low concentrations.

Cette invention a pour objet une série de dérivés iodo-benzamides activés utiles en tant que composés de médicaments antinéoplastiques et antiviraux. Les composés comprennent en général un groupe chélateur, un groupe de captation thiol et un groupe activateur. Le mécanisme présumé intervenant dans la prévention de la réplication du virus et des cellules cancéreuses agit par inhibition de la liaison des facteurs de transcription aux domaines de liaison des doigts de zinc. Les composés sont efficaces, à de faibles concentrations, pour inhiber la croissance d'une variété de lignées cellulaires tumorales et leucémiques humaines et animales.

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