Activated linkers and methods for making and purifying the same

Details Activated linkers and methods for making and purifying the same Activated linkers and methods for making and purifying the same

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2248006

The present invention relates to methods of making activated linkers, particularly activated linkers having reactive Michael acceptors, and to an efficient process for purifying the activated linkers which utilizes hydrophobic interaction chromatography (HIC) to separate the activated linkers based on their size and on their end-group functionality. The purified activated linkers can be used to modify biologically active molecules and improve overall production of such molecules.

La présente invention se rapporte à des procédés de fabrication de segments de liaison activés, notamment de segments de liaison activés possédant des accepteurs de Michael réactifs, ainsi qu'un procédé efficace de purification de ces segments de liaison activés par chromatographie hydrophobe (HIC) afin de les séparer en fonction de leur taille et de leur fonctionnalité de groupe terminal. Ces segments de liaison activés purifiés peuvent être utilisés pour modifier des molécules biologiquement active et améliorer leur production globale.

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