A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 31/655 (2006.01)
Patent
CA 2717867
Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) an O2 -aryl substituted diazeniumdiolate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. The compositions described herein provide numerous advantages such as increased solubility and stability of the O2-aryl substituted diazeniumdiolate in vivo. The compositions also do not induce hypotension. Methods for using the compo-sitions in anticancer treatment and prevention are also described herein.
Cette invention concerne des compositions utiles dans le traitement et la prévention du cancer. Les compositions sont faites (a) dun diazeniumdiolate à substitution O 2-aryle et (b) dun amphiphile, la quantité damphiphile étant suffisante pour produire un liposome ou une micelle. La composition décrite ici procure un certain nombre davantages, notamment une meilleure solubilité et stabilité du diazeniumdiolate à substitution O 2-aryle in vivo. Par ailleurs, les compositions ninduisent pas dhypotension. Linvention décrit aussi des méthodes dutilisation des compositions dans le traitement et la prévention du cancer.
Kosak Ken M.
Shami Paul J.
Gowling Lafleur Henderson Llp
University Of Utah Research Foundation
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