A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) C12N 9/48 (2006.01) C12N 9/96 (2006.01) A61K 9/19 (2006.01)
Patent
CA 2475738
The invention relates to pharmaceutical compositions of activated protein C with a chelating agent. Preferably, the formulation contains activated protein C, a chelating agent, a bulking agent, a buffer, and/or a salt with a reconstituted pH between about 5.5 5 and about 6.5. Alternatively, the chelating agent is added to the diluent used with the activated protein C pharmaceutical composition. The aPC pharmaceutical compositions,formulations, and uses of the invention have improved in-use stability.
L'invention concerne des compositions pharmaceutiques de protéines C activées avec un agent chélateur. De préférence, la formulation contient une protéine C activée, un agent chélateur, un agent de volume, un tampon et/ou un sel ayant un pH reconstitué entre environ 5,5 et environ 6,5. Dans un autre mode de réalisation, l'agent chélateur est ajouté au diluant utilisé avec la composition pharmaceutique à protéine C activée. Les compositions pharmaceutiques aPC, les formulations et les utilisations de l'invention présentent une stabilité d'utilisation améliorée.
Gopalrathnam Ganapathy
Huang Lihua
Riggin Ralph Meridith
Sheliga Theodore Arsay
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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