Activated protein c formulations

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/48 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) C12N 9/48 (2006.01) C12N 9/96 (2006.01) A61K 9/19 (2006.01)

Patent

CA 2475738

The invention relates to pharmaceutical compositions of activated protein C with a chelating agent. Preferably, the formulation contains activated protein C, a chelating agent, a bulking agent, a buffer, and/or a salt with a reconstituted pH between about 5.5 5 and about 6.5. Alternatively, the chelating agent is added to the diluent used with the activated protein C pharmaceutical composition. The aPC pharmaceutical compositions,formulations, and uses of the invention have improved in-use stability.

L'invention concerne des compositions pharmaceutiques de protéines C activées avec un agent chélateur. De préférence, la formulation contient une protéine C activée, un agent chélateur, un agent de volume, un tampon et/ou un sel ayant un pH reconstitué entre environ 5,5 et environ 6,5. Dans un autre mode de réalisation, l'agent chélateur est ajouté au diluant utilisé avec la composition pharmaceutique à protéine C activée. Les compositions pharmaceutiques aPC, les formulations et les utilisations de l'invention présentent une stabilité d'utilisation améliorée.

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