Activated protein c inhibits undesirable effects of...

Details Activated protein c inhibits undesirable effects of... Activated protein c inhibits undesirable effects of...

A - Human Necessities

61

K

A61K 38/16 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2574598

Activated protein C (APC), a prodrug, and/or a variant of APC may be used to inhibit undesirable effects of plasminogen activator: e.g., apoptosis or cell death of neurons and endothelial cells, brain hemorrhage or intracerebral bleeding, and/or tissue damage in a subject~s brain. Inhibition appears to act through the extrinsic pathway of death receptor signal transduction. This represents an improvement in treatment using plasminogen activator (e.g., fibrinolysis). By reducing undesirable effects, the window for fibrinolythic therapy by plasminogen activator may be widened.

La protéine C activée (APC), un promédicament et/ou un variant de la protéine APC peut-être utilisée pour inhiber les effets secondaires de l'activateur de plasminogène : par exemple, l'apoptose ou la mort cellulaire de neurones et de cellules endothéliales, l'hémorragie cérébrale ou les saignements intracérébraux et/ou la dégradation des tissus cérébraux chez un patient. Il apparaît que l'inhibition agit via le trajet intrinsèque de la traduction de signal de récepteur de mort. Ceci représente une amélioration dans le traitement utilisant ce l'activateur de plasminogène (par exemple la fibrinolyse). En réduisant les effets secondaires, la fenêtre ouvertes par la thérapie fibrinolytique via l'activateur de plasminogène s'ouvre encore un peu plus.

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