Activated rnase l as a marker for viral infections

Details Activated rnase l as a marker for viral infections Activated rnase l as a marker for viral infections

C - Chemistry, Metallurgy

12

Q

167/202, 150/9,

C12Q 1/70 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12Q 1/34 (2006.01)

Patent

CA 1337278

A first line of cellular defense against many viruses, including those causing AIDS, is activation of an intracellular biochemical system termed the 2'-5' oligoadenylate/RNase L pathway. It is well known that this pathway malfunctions in individuals with progressive AIDS-related immune dysfunction, but the mechanism of malfunction remained obscure. An inhibitor substance, released in HIV infected cells or a virus directed inhibitor of biochemical intermediates in the 2'-5'A/RNase L pathway, which by apparently physically attaching to the terminal product (RNase L) in the biochemical pathway, causes the entire system to malfunction which thus allows HIV to multiply uncontrollably has now been identified. The relative intracellular level of this newly-isolated inhibitor has prognostic significance with respect to the development of full-blown AIDS and eventual death.

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